-Made by Pandemic Studios
-The game is set in 1969, 10 years after the original. The games begins with a KGB slid show.
-Soon after, things begin. Crypto must stop the KGB from destroying America. Crypto's boss, Orthopox 13, downloaded himself into a hologram unit just before he died. Crypto finds out that the KGB have fled to Albion, and they follow. There he meets Reginald Ponsonby-Smythe, a James Bond like figure with M16 or British Intelligence. Also he meets a rogue KGB agent named Natalya. They find that the KGB have created a type of spore that can mutate a human into a monster. Eventually Ponsonby betrays Crypto, revealing that he is British Intelligence, part of Majestic, Sector 16, the British branch.
-Then Crypto learns that the KGB have a base in Takoshima. Arriving in Takoshima, Crypto is to rescue a man named Dr. Go(parody of Dr. No). He provides info and access to the KGB base hidden in the island's volcano. Crypto and Natalya must break into this base and they eventually find out that the person behind most of this is the Russian Premier Milenkov. He shows them a clip showing his men using the spores on a Takoshimese girl, who tranforms into a Godzilla-like creature, called Kojira. After defeating the monster, Crypto and Natalya travel to Tunguska, a remote scientific industrial town in Russia. Crypto finds another alien race has taken over the town, The Blisk. They are an enemy the Furons fought during the Martian War. Pox realizes the Tunguska event of 1908 was actually a Blisk warship crashing on Earth. After rescuing Natalya from a Blisk gas bubble, the 2 go to the Moon where Project Solaris is.
-There they find a superweapon designed to bombard the Earth with Blisk spores and radiation, granting the Blisk control of Earth as their new irradiated, water-logged homeworld. Using his ability to "body snatch" Crypto disguises himself as cosmonaut Leonid, the head scientist and convinces the rest of the cosmonauts to turn against the Blisk. Crypto also manages to sabotage the firing mechanism for the weapon. So Milenkov confronts Crypto and he reveals that they have been controlling the Russian government. Natalya and Crypto destroy the Blisk Hive Mind with a virus called O.M.G.W.T.F. After fighting Milenkov, Crypto relaxes in his saucer with Natalya in bed.
- Reginald Ponsonby-Smythe - is secretly leader of the Majestic command in Albion. He helps Crypto in two missions, but then betrays him. He is killed by Crypto after he escapes. He speaks with a posh British accent and wields an umbrella rifle. It is discovered through mind-scanning Ponsonby or listening to his speech during his final battle, that he was in love with Silhouette from the original game.
- Milenkov - The main antagonist. He is the Premier of the Soviet Union and secretly the leader of the Blisk.